So, if I can tell one I can suggest the Yellow House in Kuala Lumpur, but because I know for sure they are very serious. I have been with them for a while, and Shyam the owner is a friend.
But if I have to choose one more generic topic, surely climate change should be taken as the first point. Followed by the fight against fake news.
Other important topics are access to primary resources such as water, food and the internet for everyone. so, There are a lot of things.
What you do with donations is great. Being able to support projects directly is certainly a big step.
The advs work well to find the project. Maybe one thing that could be done and make it easier to find these projects. Could be create a website that combine these projects, so that users can discover and support projects from one place. A sort of repository of NGOs and projects.